Landmark EM Papers
A curated, searchable index of key Emergency Medicine papers and clinical trials — the evidence base every EM physician should know. Search by keyword, trial name, journal, or clinical category.
72 papers · 33 named trials
NEJMGI & Hepatology
Acute Abdomen in the Modern Era
2024-07-04
BMJEndocrine & Metabolic
New advances in type 1 diabetes
2024-04-20
BMJMiscellaneous
Therapeutic advances in rheumatoid arthritis
2024-04-13
EMJED Operations & Systems
Ten Second Triage: A Novel and Pragmatic Approach to Major Incident Triage
2024-01-01
JAMA PsychiatryCardiac & ECG
ADHD Medications and Long-Term Risk of Cardiovascular Diseases
2023-11-22
BMJNeurology & Stroke
Spinal metastases and metastatic spinal cord compression: summary of NICE guidelines
2023-10-28
BMJTrauma
Are hard collars necessary for older people with odontoid neck fractures?
2023-06-10
BMJHaematology & VTE
Prevention of venous thromboembolism in patients with cancer
2023-06-01
Alcohol Clin Exp ResToxicology
Medications for treating alcohol use disorder: A narrative review
2023-05-12
EMJToxicology
Drink and injection spiking: how to approach an increase in presentations
2023-04-01
EMJToxicology
High-potency benzodiazepine misuse in opioid dependent patients: use naloxone with care
2023-03-01
EMJTrauma
Does pre-injury clopidogrel use increase the risk of intracranial haemorrhage post head injury? A systematic review and meta-analysis
2023-03-01
BMJMental Health
Immediate management of acute psychological trauma in conflict zones
2023-02-08
BMJPaediatrics
Is immobilisation required for toddler's fracture of the tibia?
2023-01-14
EMJHaematology & VTE
Thromboprophylaxis in ambulatory ED patients managed with lower limb immobilisation after injury
2023-01-01
EMJRespiratory & Airway
Pulmonary embolism management in the emergency department part 2
2023-01-01
EMJRespiratory & Airway
Pulmonary embolism diagnosis part 1: clinical assessment at the front door
2022-12-01
EMJHaematology & VTE
Semi-rigid knee splints for injury and risk of symptomatic VTE: an exploratory retrospective analysis
2022-12-01
BMJED Operations & Systems
Supporting healthcare workers with work related stress
2022-11-26
EMJCardiac & ECG
Starting anticoagulation for atrial fibrillation in the emergency department safely
2022-11-01
BMJED Operations & Systems
Medical photography using mobile devices
2022-09-10
NEJMResuscitation & Cardiac ArrestDOSE VF
Double Sequential Defibrillation for Refractory Ventricular Fibrillation (DOSE VF)
2022-08-24
EMJTrauma
Non-sterile gloves vs sterile gloves for suturing traumatic wounds in the ED
2022-07-01
Acad Emerg MedPain & Sedation
Periosteal block versus IVRA for reduction of distal radius fractures: an RCT
2022-06-29
EMJUltrasound & Imaging
SONO case series: RUQ point-of-care ultrasound in assessment of the gallbladder
2022-06-01
LancetResuscitation & Cardiac ArrestRePHILL
Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL)
2022-03-07
BMJHaematology & VTE
Diagnosis of DVT with D-dimer adjusted to clinical probability: prospective diagnostic management study
2022-02-15
JAMAResuscitation & Cardiac Arrest
Effect of Intra-arrest Transport, ECPR, and Immediate Invasive Assessment on Functional Neurologic Outcome
2022-02-01
JAMACOVID-19RECOVERY-RS
RECOVERY RS: Effect of Noninvasive Respiratory Strategies on Acute Hypoxemic Respiratory Failure and COVID-19
2022-01-24
BMJMusculoskeletal & FracturesDRAFFT2
Surgical fixation with K-wires versus casting in adults with distal radius fracture (DRAFFT2)
2022-01-22
NEJMRenal & ElectrolytesPLUS
Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults (PLUS Trial)
2022-01-18
NEJMRenal & Electrolytes
Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis
2022-01-18
BMJToxicology
Managing snakebite
2022-01-15
EMJUltrasound & Imaging
SONO case series: an 85-year old woman with left hip pain
2022-01-01
Am J Emerg MedCardiac & ECG
Emergent cardiac outcomes in patients with normal ECG in the ED
2022-01-01
EMJPain & Sedation
We Need to Talk About Codeine: an Implementation Study to reduce high-strength co-codamol discharge from ED
2021-12-01
EMJRespiratory & Airway
Studying ApOx in the ED: forget associations, the truth is in the design
2021-12-01
EMJPain & Sedation
Evaluation of a state law on opioid-prescribing behaviour
2021-12-01
JAMAResuscitation & Cardiac Arrest
Effect of IV or IO Calcium vs Saline on Return of Spontaneous Circulation in Adults With OHCA
2021-11-30
CirculationCardiac & ECGEPIC
Anterior-Lateral Versus Anterior-Posterior Electrode Position for Cardioverting Atrial Fibrillation (EPIC)
2021-11-24
NEJMCOVID-19
Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab
2021-11-18
Curr Cardiol RepCardiac & ECG
Diagnosis of Occlusion MI in Patients with LBBB and Paced Rhythms
2021-11-17
JAMAPaediatricsCAP-IT
Effect of Amoxicillin Dose and Treatment Duration on Antibiotic Re-treatment in Children With CAP (CAP-IT)
2021-11-02
J Trauma Acute Care SurgTraumaP-CAT
Small (14 Fr) percutaneous catheter vs open chest tube for traumatic hemothorax: a multicenter RCT
2021-11-01
ChestRespiratory & Airway
Safety of Thoracentesis and Tube Thoracostomy in Patients With Uncorrected Coagulopathy
2021-11-01
Ann SurgGI & HepatologyDINAMO
Nonantibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO study)
2021-11-01
Ann Emerg MedGI & Hepatology
Efficacy of Initial Therapies for Bleeding from Esophageal Varices in Adult Patients with Cirrhosis
2021-11-01
NEJMResuscitation & Cardiac ArrestTTM2
Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest (TTM2)
2021-06-17
LancetCOVID-19RECOVERY
Tocilizumab in Patients Admitted to Hospital with COVID-19 (RECOVERY)
2021-05-01
NEJMCOVID-19RECOVERY
Dexamethasone in Hospitalized Patients with Covid-19 (RECOVERY)
2021-02-25
LancetTraumaCRASH-3
Tranexamic Acid for Treatment of Significant Traumatic Brain Injury (CRASH-3)
2019-10-14
JAMACardiac & ECGHiSTORIC
High-Sensitivity Cardiac Troponin I at Presentation in Patients With Suspected ACS (HiSTORIC)
2019-09-08
JAMAResuscitation & Cardiac ArrestPART
Effect of a Strategy of Initial Laryngeal Tube Insertion vs Endotracheal Intubation on 72-Hour Survival in Adults With OHCA (PART)
2018-08-28
NEJMTraumaPAMPer
Effect of Prehospital Plasma during Air Medical Transport for Trauma (PAMPer)
2018-07-26
NEJMResuscitation & Cardiac ArrestPARAMEDIC-2
A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest (PARAMEDIC-2)
2018-07-18
JAMAResuscitation & Cardiac ArrestAIRWAYS-2
Bag-Mask Ventilation vs Tracheal Intubation for OHCA (AIRWAYS-2)
2018-07-18
NEJMNeurology & StrokeEXTEND-IA TNK
Tenecteplase before Thrombectomy for Ischaemic Stroke (EXTEND-IA TNK)
2018-05-16
NEJMRenal & ElectrolytesRELIEF
Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery (RELIEF)
2018-05-10
NEJMRenal & ElectrolytesSALT-ED
Balanced Crystalloids versus Saline in Noncritically Ill Adults (SALT-ED)
2018-03-01
NEJMRenal & ElectrolytesSMART
Balanced Crystalloids versus Saline in Critically Ill Adults (SMART)
2018-03-01
NEJMNeurology & StrokeDEFUSE 3
Thrombectomy for Stroke at 6 to 16 Hours with Perfusion-Imaging Selection (DEFUSE 3)
2018-01-24
NEJMNeurology & StrokeDAWN
Thrombectomy 6 to 24 Hours after Stroke with Mismatch (DAWN)
2018-01-04
NEJMHaematology & VTETRICS-III
Liberal or Restrictive Transfusion after Cardiac Surgery (TRICS III)
2017-11-12
NEJMRespiratory & AirwayFELLOW
Apneic Oxygenation during Endotracheal Intubation (FELLOW)
2016-02-18
NEJMResuscitation & Cardiac Arrest
Trial of Continuous or Interrupted Chest Compressions during CPR (PART Trial)
2015-11-09
NEJMRespiratory & AirwayFLORALI
High-Flow Nasal Oxygen vs Noninvasive Ventilation for Acute Hypoxemic Respiratory Failure (FLORALI)
2015-06-04
NEJMInfectious Disease & SepsisProMISe
Trial of Early, Goal-Directed Resuscitation for Septic Shock (ProMISe)
2015-04-02
NEJMInfectious Disease & SepsisARISE
Goal-Directed Resuscitation for Patients with Early Septic Shock (ARISE)
2014-10-01
NEJMInfectious Disease & SepsisProCESS
A Randomized Trial of Protocol-Based Care for Early Septic Shock (ProCESS)
2014-03-18
NEJMResuscitation & Cardiac ArrestTTM
Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest (TTM)
2013-12-05
LancetTraumaCRASH-2
Effects of Tranexamic Acid on Death and Thromboembolic Events in Trauma (CRASH-2)
2010-07-03
NEJMCardiac & ECGPLATO
Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes (PLATO)
2009-09-10